Lipid Content of Tumors.
نویسندگان
چکیده
Studies bearing on the lipids of tumors have been made in most cases either with regard to the changes of the lipid content of the blood of tumor animals and patients or the relation between the lipids and the growth of the tumors. Of the lipids, cholesterol has been most frequently studied. Roffo (1) reported that cholesterol is concerned with the development of experimental tumors and that an increase of cholesterol in blood plasma characterizes the so-called precancerous stage. Also the cells of malignant tumors cause considerable destruction of absorbed cholesterol. Mattick and Buchwald (2) found hypercholesterolemia in the plasma of cancer patients with little change in the content of the corpuscles. They found also an accumulation of total fatty acids in the plasma. Kahn (3) showed that malignant tumors contained large amounts of cholesterol and its esters while the cholesterol content of the blood serum was lower than normal. Bolaffi (4) could not find any particular change in the cholesterol content of the blood of tumor mice, but found an increase of cholesterol ester in the whole organism. Burgheim (5) by histochemical examination found larger amounts of cholesterol in malignant tumors than in benign ones and also found a temporary increase of cholesterol in the blood of cancer patients after treatment by x-rays. He believed that this increase of cholesterol in the blood was caused by the destruction by the x-rays of cells containing large amounts of cholesterol. Phosphorus of the blood of the tumor animals interested Haam (6), Enselme (7) and Roffo (8) who made studies of the phospholipids and nucleoproteins. The lipids of tumor tissue were first investigated by Bullock and Cramer (9) who found that they showed both quantitative and qualitative differences in different strains of tumors and that rapidly growing tumors contained more phospholipid and less cholesterol than the slowly growing ones.
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 11 4 شماره
صفحات -
تاریخ انتشار 2013